DSpace About DSpace Software
 

Digital Library >
Bộ danh mục tài liệu thư viện - Viện Hải dương học - VNIO library catalogue >
Công bố khoa học ở tạp chí quốc tế - International research papers (Bibliographic record and/or full-text) >

Please use this identifier to cite or link to this item: http://tvhdh.vnio.org.vn:8080/xmlui/handle/123456789/21539

Title: Mycophenolic Acid Derivatives from Vietnamese Marine Sponge-derived Penicillium sp. 1901NT-2.53.1 Strain and their Antiproliferative Activity
Authors: Khmel, Olga O.
Phan, Thi Hoai Trinh
Ngo, Thi Duy Ngoc
Chingizova, Ekaterina A.
Drozdov, Konstantin A.
Popov, Roman S.
Van, Tran Thi Thanh
Huynh, Hoang Nhu Khanh
Pham, Duc Thinh
Yurchenko, Ekaterina A.
Yurchenko, Anton N.
Keywords: Vietnam
Marine sponge
sponge-associated fungi
Bioactive compound
Penicillium sp. 1901NT-2.53.1
Issue Date: 2025
Series/Report no.: Current Bioactive Compounds, Vol. 21, 2025;DOI:10.2174/0115734072350564250206114002
Abstract: Background Marine sponges and sponge-associated fungi are rich sources of bioactive compounds with pharmacological potential. However, the secondary metabolites of Vietnamese marine sponge-derived fungi have been poorly studied. Objective The aim of this study was to investigate the low-molecular-weight compounds in the extract of Penicillium sp. 1901NT-2.53.1 fungus isolated from the Vietnamese marine sponge Cinachyrella sp., and the antiproliferative activity of the isolated compounds. Methods The structures of isolated compounds were elucidated using spectroscopic methods. The cell viability effects of the compounds were evaluated using MTT assay. Molecular docking was performed using SwissDock. Results UPLC-MS data suggested the presence of beauvericin, citreorosein, benzopyran and chlorotetracycline derivatives, 2-chloro-1,3,8-trihydroxy-6-(hydroxymethyl)anthracene-9,10- dione and ergosterol peroxide in the fungal extract. Chromatographic separation of the extract resulted in the isolation of three derivatives of mycophenolic acid (MPA), namely penicacids G and K and 4-hydroxy-MPA. Penicacid K was isolated from a natural source for the first time. Penicacid G inhibited the viability of human normal HaCaT keratinocytes with IC50 of 88.3 μM and 72.9 μM for 24 h and 48 h of treatment, respectively. Moreover, penicacid G arrested the proliferation of HaCaT keratinocytes. Both penicacids K and G can interact with the active site of IMPDH2, similar to other derivatives of MPA; however, the differences in their structures are important. Conclusion Due to the selective action on cancer cells and good druggability, penicacid G may be interesting as an antiproliferative anticancer compound.
URI: http://tvhdh.vnio.org.vn:8080/xmlui/handle/123456789/21539
ISSN: 1573-4072
Appears in Collections:Công bố khoa học ở tạp chí quốc tế - International research papers (Bibliographic record and/or full-text)

Files in This Item:

There are no files associated with this item.

View Statistics

Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.

 

Valid XHTML 1.0! DSpace Software Copyright © 2002-2012  Duraspace - Feedback