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Changes in microbial community composition affect bioactivities of mucus isolated from coral acropora millepora

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dc.contributor.author Dao, Manh Cuong
dc.contributor.author Phan, Thi Thu Hien
dc.contributor.author Bui, Van Ngoc
dc.date.accessioned 2024-09-13T08:38:36Z
dc.date.available 2024-09-13T08:38:36Z
dc.date.issued 2022
dc.identifier.issn 2815-5955 (print); 2815-5912 (online)
dc.identifier.uri http://tvhdh.vnio.org.vn:8080/xmlui/handle/123456789/21244
dc.description.abstract Antibioticresistance is increasingly popular together with emerging diseases presentsan urgent requirement for more and more discovery of novel marine bioactive compounds. Paired-end reads of 16S rRNA sequenceof bacteria living in the coralAcropora milleporaobtained by the Illumina next-generation sequencing technology to be processed by DADA2 pipeline, phyloseq and ggplot2 packagesshowed thatbleached coral mucus hadan alpha diversity to be higher than healthy coral mucus.The coral surface mucuslayer (SML) of healthy coral exhibited higher growth inhibitionactivity to Vibrio parahaemolyticusteststrainthan that of bleached coral inany amount(10 –30 μL). The cytotoxicity againstthecolon cancer cell line HCT116 was also clearly observed when treated with healthy SMLand was1.5 times higher than mucuswastaken from bleached coral. The composition of the microbial community was shiftedwhen coralschangedfrom a healthy state to a bleached one,resulting in the reductionof antibacterial activity and cytotoxicity. vi,en
dc.language.iso en vi,en
dc.relation.ispartofseries Vietnam Journal of Biotechnology, 20(2), 387–392. https://doi.org/10.15625/1811-4989/16984;https://vjs.ac.vn/index.php/vjbt/article/view/16984
dc.subject Coral vi,en
dc.subject Acropora millepora vi,en
dc.subject Antibacterial activity vi,en
dc.subject Anticancer activity vi,en
dc.subject Coral-associated bacteria vi,en
dc.subject Coral bleaching vi,en
dc.title Changes in microbial community composition affect bioactivities of mucus isolated from coral acropora millepora vi,en
dc.type Working Paper vi,en


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