Abstract:
Chemical study of the fermentation culture of the marine-derived fungal strain
Penicillium sp. OPR23-FS02 led to isolation of ten secondary metabolites, including
two terpenes, purpuride (1) and penioxalicin (2) and eight polyketides, trans-
3,4-dihydro-3,4,8-trihydroxynaphthalen-1(2H)-one (3), chloromonilinic acid B (4),
chrysophanol (5), emodin (6), ω-hydroxyemodin (7), questin (8), endocrocin (9),
and ergochrome F (10). Their structures were elucidated by analyzing their NMR
and HRESI mass spectra and comparing with the literature data. Compound 9 was
weakly cytotoxic against HepG2 cell line, with an IC50 value of 89.86 ± 2.63 μM.
Compounds 4 and 10 showed antimicrobial effect against Enterococcus faecalis
whereas 6 inhibited Bacillus cereus growth, with the same MIC values of 64 μM.