Terpenes and polyketides from the marine-derived fungus Penicillium sp. OPR23-FS02 with cytotoxic and antimicrobial effects

Abstract

Chemical study of the fermentation culture of the marine-derived fungal strain Penicillium sp. OPR23-FS02 led to isolation of ten secondary metabolites, including two terpenes, purpuride (1) and penioxalicin (2) and eight polyketides, trans- 3,4-dihydro-3,4,8-trihydroxynaphthalen-1(2H)-one (3), chloromonilinic acid B (4), chrysophanol (5), emodin (6), ω-hydroxyemodin (7), questin (8), endocrocin (9), and ergochrome F (10). Their structures were elucidated by analyzing their NMR and HRESI mass spectra and comparing with the literature data. Compound 9 was weakly cytotoxic against HepG2 cell line, with an IC50 value of 89.86 ± 2.63 μM. Compounds 4 and 10 showed antimicrobial effect against Enterococcus faecalis whereas 6 inhibited Bacillus cereus growth, with the same MIC values of 64 μM.