Ergostane steroids from Aspergillus sp. M904 in Vietnam

dc.contributor.author	Trinh, Thi Thanh Van
dc.contributor.author	Nguyen, Thi Mai Anh
dc.contributor.author	Vu, Van Nam
dc.contributor.author	Nguyen, Thuy Linh
dc.contributor.author	Le, Thi Hong Minh
dc.contributor.author	Brian, T. Murphy
dc.contributor.author	Doan, Thi Mai Huong
dc.contributor.author	Pham, Van Cuong
dc.date.accessioned	2025-02-10T03:03:05Z
dc.date.available	2025-02-10T03:03:05Z
dc.date.issued	2024
dc.identifier.issn	1859-3097 (print); 2815-5904 (online)
dc.identifier.uri	http://tvhdh.vnio.org.vn:8080/xmlui/handle/123456789/21369
dc.description.abstract	Seven ergostane steroids were isolated from the cultures of Aspergillus sp. M904, an endophytic fungus isolated from the marine sediment sample collected at a depth of ten meters in Binh Dinh, Vietnam. These compounds include 5α,6α-epoxy-(22E,24R)-ergosta-8(14),22-diene-3β,7α-diol (1), 5α,6α-epoxy-(22E,24R)-ergosta-8(9),22-diene-3β,7α-diol (2), ergosterol (3), ergosterol peroxide (4), 3β,5α,6α-trihydroxy-ergosta-7,22-diene (5), 3β,5α,9α-trihydroxy-ergosta-7,22-diene-6-one (6), 3β-hydroxy-5α,9α-epoxy-ergosta-7,22-dien-6-one (7). Their structures were identified through MS and NMR data analyses. All compounds were evaluated for their antimicrobial activity against a panel of clinically significant microorganisms. Compounds 1–7 had inhibitory activity against from one to six tested strains with MIC values from 64–256 µg/mL.	vi,en
dc.language.iso	en	vi,en
dc.relation.ispartofseries	Vietnam Journal of Marine Science and Technology, 24(4): pp. 419–428, 2024, https://doi.org/10.15625/1859-3097/22128;
dc.subject	Fungus	vi,en
dc.subject	Aspergillus	vi,en
dc.subject	Ergostane steroid	vi,en
dc.title	Ergostane steroids from Aspergillus sp. M904 in Vietnam	vi,en
dc.type	Working Paper	vi,en