| dc.description.abstract |
Antimicrobial resistance (AMR) has increased significantly due to the widespread transmission of multidrugresistant (MDR) bacteria and antibiotic-resistance genes (ARGs) within and between animals, environments,
and humans. Unfortunately, the AMR situation in the coastal areas is little known. In this study, we investigated
the occurrence and distribution of MDR Enterobacteriaceae from water and sediment samples collected in Nha
Trang Bay, Viet Nam. Overall, 48/107 (45.8 %) identified and isolated bacteria belong to risk group 2 pathogens.
More than 57 % of Enterobacteriaceae isolates exhibited MDR phenotypes, in which Escherichia coli, Klebsiella
pneumoniae, and Citrobacter freundii were the most prevalent species. In addition, eight ARGs including sul1, sul2,
sul3, tetQ, tetB, mecA, blaVIM and blaKPC were detected with high abundance in most of water and sediment
samples. Notably, class 1 integron-integrase gene intI1 was widely distributed (95.8 %) in all samples with a total
absolute abundance of 2.9 × 105 copies/ml water and 9.7 × 107 copies/g sediment. We also identified significant
relationships between sul3, tetB, blaVIM, blaKPC and intI1 with bacterial density, chlorophyll A, phosphorus and
temperature. These observations suggest that intI1 gene and nutrients could promote the emergence and propagation of antibiotic-resistance bacteria (ARB) and ARGs in the Nha Trang Bay. |
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